USMLE USMLE : United States Medical Licensing Examination

  • Exam Code: USMLE
  • Exam Name: United States Medical Licensing Examination
  • Updated: Jul 23, 2026
  • Q & A: 400 Questions and Answers

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USMLE Step 1 is a one-day (8 hours) examination. It includes 322 multiple-choice questions divided into 7 blocks of 46 items (60 minutes are given for completion of each block).

USMLE Step 3 is open to candidates who already hold their USMLE Step 1 and Step 2 certificates. Step 3 is a two-day exam that assesses whether candidates are able apply medical knowledge and understanding of biomedical and clinical science essential to unsupervised medical practice. This is the final USMLE exam which leads to the license to practice medicine without supervision - the ultimate goal of medical students and professionals willing to practice medicine in the United States. Step 3 represents the final assessment of physicians assuming independent responsibility for delivering general medical care.

Reference: http://www.usmle.org/step-1/#question-formats

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USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Topic 1: Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Skin Neoplasms
  • 2. Inflammatory Skin Disorders
Topic 2: Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Orthopedic Disorders
  • 2. Rheumatologic Diseases
Topic 3: Human Development- Growth and Development
  • 1. Embryology
  • 2. Developmental Abnormalities
Topic 4: Respiratory System- Pulmonary Medicine
  • 1. Lung Diseases
  • 2. Airway Disorders
Topic 5: Endocrine System- Hormonal Regulation and Disease
  • 1. Thyroid Disorders
  • 2. Pituitary Disorders
  • 3. Adrenal Disorders
Topic 6: Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Physiology
  • 2. Reproductive Disorders
Topic 7: Multisystem Processes and Disorders- Systemic Conditions
  • 1. Neoplasia
  • 2. Infectious Diseases
  • 3. Nutrition
Topic 8: Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Pathology
  • 2. Renal Physiology
Topic 9: Gastrointestinal System- Digestive System Disorders
  • 1. Gastrointestinal Pathology
  • 2. Liver Disease
Topic 10: Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neuroanatomy
  • 2. Neuropathology
  • 3. Neurologic Diseases
Topic 11: General Principles- Foundational Medical Sciences
  • 1. Genetics
  • 2. Physiology
  • 3. Biochemistry
  • 4. Pharmacology
  • 5. Pathology
  • 6. Immunology
  • 7. Microbiology
  • 8. Behavioral Sciences
Topic 12: Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Leukemias and Lymphomas
  • 2. Anemias
  • 3. Coagulation Disorders
Topic 13: Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Vascular Pathology
  • 2. Heart Disease

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