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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A clinical microbiology laboratory is preparing to validate a new molecular assay for the detection of methicillin-resistant Staphylococcus aureus (MRSA). To assess the positive predictive value (PPV) of the assay, they need to know:

A) The number of true negative results divided by the total number of true negative and false positive results.
B) The number of true positive results divided by the total number of positive test results.
C) The number of true positive results divided by the total number of true positive and false negative results.
D) The number of true negative results divided by the total number of negative test results.

2. A previously healthy 28-year-old female develops a severe, watery diarrhea after attending a picnic where she consumed potato salad that had been left unrefrigerated for several hours. Stool culture reveals numerous Gram-positive bacilli. Further biochemical testing shows the organism is beta-hemolytic on blood agar and produces a heat-stable enterotoxin. The MOST likely causative agent is:

A) Clostridium difficile
B) Bacillus cereus
C) Vibrio cholerae
D) Staphylococcus aureus

3. A patient develops a localized skin infection after being bitten by a tick. The infection is characterized by a slowly expanding erythematous rash with central clearing (erythema migrans). The MOST likely causative agent is:

A) Borrelia burgdorferi
B) Rickettsia rickettsii
C) Anaplasma phagocytophilum
D) Ehrlichia chaffeensis

4. A patient with a history of exposure to bats in a cave develops progressive neurological symptoms, including hydrophobia. The MOST likely viral etiology is:

A) Rabies virus
B) West Nile virus
C) Japanese encephalitis virus
D) Herpes simplex virus encephalitis

5. A research laboratory is investigating the mechanism of action of a novel antiviral compound. In vitro studies demonstrate that the compound effectively inhibits the replication of a specific enveloped RNA virus. Further analysis reveals that the compound does not interfere with viral entry, genome replication, or protein synthesis. However, electron microscopy of infected cells treated with the compound shows an accumulation of viral glycoproteins within the endoplasmic reticulum and Golgi apparatus, with a significant reduction in the release of infectious virions. The MOST likely target of this antiviral compound is:

A) Viral glycoprotein trafficking and maturation
B) Viral RNA-dependent RNA polymerase
C) Viral protease responsible for polyprotein cleavage
D) Host cell membrane fusion machinery

Solutions: